
In a February 2026 NoSilverBullet4PD webinar, Rick Helmich, MD, with the Donders Institute for Brain, Cognition and Behaviour in The Netherlands, spoke on what he calls “the brain’s backup plan,” of the brain’s compensatory mechanism. This refers to the ability of cortical areas not directly damaged by Parkinson’s Disease (PD) to take over functions that dopamine-dependent circuits can no longer reliably perform. He also identified the two key brain regions involved in this compensation and what causes those regions to fail.
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